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With the assistance of complexes, such as Drosha/DGCR, Exportin-5/RAN-GTP, and Dicer/TRBP, primary miRNAs (pri-miRNAs) transcribed from the non-coding region of miRNA genes are processed to form mature miRNAs (Fig

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Clinical trials have demonstrated substantial reductions in hemoglobin A1c levels (up to 2.5% reduction) in type 2 diabetes, while weight management trials showed 15-21% weight loss in adults with obesity without diabetes