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Spine immobility from fibrosis and ossification is a major complication Vision damaging eye inflammation can also occur Fracture of fused spine can lead to damage to the spinal cord Stiffness of the spine and chest wall can make breathing difficult Inflammation of aorta or major artery coming from heart Inflammation of the kidney is rare Early heart disease due to chronic inflammation leading to heart attacks can occur in ankylosing spondylitis Early and effective therapy can prevent most of these complications

14,15 It has also been noted that endogenous GHK declines with age, with higher levels in young healthy people as compared to older adults around age 60

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When it binds with copper (Cu), it activates enzymes responsible for: connective tissue formation antioxidant defense cellular respiration It also regulates free copper ions to prevent oxidative stress, keeping the system balanced rather than reactive

Beyond anti-inflammation, -3 PUFAs also exhibit potent antioxidant properties by activating the Nrf2 signaling pathway (41)