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However, before this can be considered a serious argument, it should probably first be proven that levodopa treatment increases the DA or NM concentrations in the remaining DA neurons of PD patients indeed

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Similarly, in the CANVAS outcome study, discussed in detail below, LDL cholesterol and HDL cholesterol were also marginally increased in the canagliflozin treated group (LDL cholesterol 4-5 mg/dL and HDL cholesterol 2-3 mg/dL) (144)