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A pooled analysis of the SELECT, FLOW, STEP-HFpEF, and STEP-HFpEF DM trials examined 1,461 patients with HFpEF, most of whom had overweight or obesity

The Randall plaque doctrine suggests that kidney stones begin as calcium plaques on the basement membrane of the loop of Henle, and that large numbers of idiopathic CaOx stones attach to the plaques to form deposits deep in the renal interstitium