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Intima-media thickness (IMT) measured at a common carotid artery level is widely used as an effective, non-invasive surrogate measure of atherosclerosis [89]

Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate glucose levels in the blood and promotes weight loss by enhancing feelings of fullness

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Thus, the diminished PAG leptin signaling ensures adequate sympathetic activation and glucose mobilization to meet the metabolic needs associated with noxious stimuli or negative energy balance

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