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Safety Considerations and Who Should Avoid Schedule Changes Patients with a history of adverse reactions to tirzepatide, those on concurrent medications affecting metabolism, or individuals with renal or hepatic impairment should never adjust dosing intervals without explicit provider approval

For Wegovys cardiovascular indication, you need documented established cardiovascular disease, meaning a prior heart attack, stroke, or known coronary artery disease, plus a BMI of 27 or higher

Pickering IJ, Cheng Q, Rengifo EM, Nehzati S, Dolgova NV, Kroll T, et al

-ketoglutarate-dependent KDM6 histone demethylases and interferon-stimulated gene expression in lupus

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Some people report broader changes beyond food, such as less interest in alcohol or other rewarding behaviors