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Elevated NAD+ activates sirtuins, particularly SIRT1, which function as master regulators of longevity pathways

Symptoms of severe vitamin B12 deficiency can include visual disturbances, severe joint pain, paresthesia (tingling in the hands and feet), memory problems, depression, anxiety, poor muscle function, ataxia (impaired balance and coordination), changes in reflexes and even infertility

(50 mg IM twice weekly slowed functional decline by ~43% in early-stage ALS.) Clinical safety of ultra-high-dose methylcobalamin in patients with amyotrophic lateral sclerosis: Open-label extension (long-term safety data)

doi: 10.1038/oby.2010.296

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