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The trial also featured a "novel, patient-centric approach to clinical trial design." Placebo participants who regained 50% or more of their weight were eligible for rescue therapy with orforglipron

used gold standard hyperinsulinemic euglycemic and hyperglycemic clamp methods in 117 patients with T2D to confirm a significant improvement in the clamp disposition index, a measure reflecting both increased insulin secretion and sensitivity, in tirzepatide 15 mg vs

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