Scientists discovered that GLP-1 could lower blood sugar levels in people, leading pharmaceutical companies to explore its potential as a diabetes treatment
In addition, suspected side effects can be reported directly to the MHRA via the Yellow Card scheme at yellowcard.mhra.gov.uk or through the Yellow Card app
Direct stimulation of these receptors may contribute to nausea and emesis, particularly during the initial weeks of treatment or following dose escalation
Meta-analyses suggest that GLP-1RAs can lead to an average BMI reduction of 12 kg/m 2 , a decrease in waist circumference of several centimeters, and total weight loss of 5%7% in some studies (85)
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