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Bedtime administration is recommended to align with natural melatonin rhythms

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however, in 2010 it was reported that low bioavailability precluded further development

Overall, extensive experimental evidence demonstrates that estrogen replacement therapies improve skin quality (thickness, elasticity, hydration), accelerate healing, and protect against the development of chronic wounds in aged humans and estrogen-deprived animal models (Ashcroft et al., 1997

Not my idea, but it works