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The loss of HNF1A and FXYD2 may induce membrane hyperpolarization, thereby impairing insulin secretiona mechanism relevant to both maturity-onset diabetes of the young type 3 (MODY3) and T2D (Weng et al., 2023)

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For example, insulin levels and hemoglobin A1C, which is a measure of glucose control, worsens [and] lipid profile components like total cholesterol, triglycerides, and low-density lipoprotein increase