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Interestingly, it was recently found that chronic shift lag induces NK cells aging and impairs immunosurveillance 99

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Therefore, score-guided adjustments are preferred over reflex up-titration (Table 1) (93, 101)

The mice were pretreated with dopamine antagonist haloperidol (5.0 mg/kg i.p.) and subsequently treated with amphetamine (20 mg/kg i.p.1, 2, 4 and 10 days after haloperidol pre-treatment), which is usually used for the study of behavioral supersensitivity to an amphetamine stimulating effect