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Immune cell-derived cytokines contribute to obesity-related inflammation, fibrogenesis and metabolic deregulation in human adipose tissue

GLP-1RA activate the cAMP/PKA pathway leading to phosphorylation of sodium-hydrogen exchanger 3 (NHE3) in renal proximal tubular cells, increasing natriuresis and diuresis and lowering blood pressure

The ADA recommends that if blood sugar targets are not being met with metformin and/or basal insulin, then Victoza should be considered

Nausea or vomiting occurs in 3 to 8 percent of GLP-1 trial participants, but the vast majority resolve without discontinuing therapy

Lowering the dose often improves both energy and mood without losing the benefits

Science 264(5166):17721775