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In agreement with this, kinetic modelling suggests that MDHAR will be the predominant contributor to ascorbate regeneration (Polle 2001)

Because metabolites represent downstream products of cellular signaling and metabolic networks integrating genetic, environmental, and lifestyle influences, metabolomic profiling provides a functional readout of biological state

This doesn't indicate danger, just absence of data

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Moreover, CRC cells exhibit marked metabolic plasticity, in which FAO serves as a key mitochondrial mechanism for energy compensation [13, 14]