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Scientists are unsure whether water retention can cause headaches, but headaches have been a reported symptom in those who reported suffering from water retention

Further medicinal chemistry optimization to improve structure activity relationship and potency as well as safety and toxicity, pharmacokinetic (bioavailability, half-life and biodistribution) and rodent in vivo studies will follow to determine the compounds potential to become suitable candidates for further development

This included less fat tissue, more muscle mass, better skin elasticity and hair condition and a feeling of well-being

In addition, Guo et al

However, the theory has not stood up in the field