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Hypersensitivity reactions may manifest in various ways, ranging from local injection site reactions such as erythema, swelling, and pruritus to more severe systemic reactions including angioedema, anaphylaxis, or generalized urticaria

Here is the critical conversion to memorize

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1 General side-effects of hydroxo-B12 listed in the British National Formulary (BNF) are diarrhoea, dizziness, headache, hot flushes, nausea, skin reactions and urine discolouration

On Henley Isle, a small sliver of land in the river, which was mostly submerged by floods in 2014, they have designed a white lozenge-shaped boat of a house, shaped so that rising waters will happily flow around it