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Pyridoxine is one of three natural forms of vitamin B (along with pyridoxal and pyridoxamine) and is a water-soluble vitamin that must be obtained from diet or supplements

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Mechanistically, it acts as a ghrelin mimetic, binding the growth hormone secretagogue receptor (GHS-R1a) the receptor for the endogenous peptide ghrelin, expressed in the pituitary and hypothalamus

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Early data showed a number of issues ranging from facial redness, nausea, and spontaneous erections

Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial