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In a poll where Sermo members shared their biggest concern when prescribing GLP-1 drugs, muscle loss/frailty was the third most popular answer, with 19% of votes

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[1] [2] These effects may lead to decreased food intake and potentially impact overall nutritional status over time

Notably, the risk of major depressive disorder was the highest among female GLP-1 RA users, with a 216% elevated risk (HR: 3.16, 95% CI 2.983.34) compared to non-users, surpassing the risks of anxiety and suicidal ideations or attempts