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Cleavable linkers can break rapidly in the special environment inside target cells, releasing the drug to achieve efficient killingmaking them especially valuable in strategies requiring fast drug release

If effective, maintain or downgrade the step

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Microglia in neurodegenerative diseases: Mechanism and potential therapeutic targets

Ricketts, C., et al

Effects of intermittent and chronic calorie restriction on mammalian target of rapamycin (mTOR) and IGF-I signaling pathways in mammary fat pad tissues and mammary tumors