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Leveraging the microbiome to understand clinical heterogeneity in depression: findings from the T-RAD study

This study provides novel findings indicating that the GLP-1R found in key neuronal pathways of the brain that regulate energy balance likely mediates liraglutide-induced weight loss

PLoS ONE 12(10):e0186668

That mechanistic basis an existing drug with a documented central nervous system anti-inflammatory effect, now confirmed across a mouse TBM model, a human brain organoid, and patient cells is what makes the finding translatable rather than merely interesting

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Semaglutide as an active ingredient is FDA-approved under the brand names Ozempic (for type 2 diabetes) and Wegovy (for weight management)