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We recommend that the optimal concentration for each specific application be determined by an initial dose-response assay

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GHS-Rlinked signaling behavior

In summary, the study demonstrates that FOXO4-DRI effectively eliminates senescent Leydig cells, improves the testicular microenvironment, and alleviates age-related testosterone secretion insufficiency, highlighting its therapeutic potential for male late-onset hypogonadism [1]

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