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Weight-loss drugs like semaglutide may melt fat, but at the cost of muscle mass

In the context of constitutive HIF-2 stabilization 75 or a defective mitochondrial electron transport chain 76 , glutamine-derived -KG is reductively carboxylated through the consumption of NADPH by IDH2 to generate citrate

Protein especially from quality sources like fish, legumes, dairy, or plant-based powders can help stimulate GLP-1, supporting better blood sugar control and reducing enzymes that inactivate it (Hira et al., 2021)

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