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A study showed that people with diabetic neuropathy got better symptoms with regular B12 shots

Generally, t 1/2 values of peptide drugs range from a few minutes to an hour ( The radioisotope probe assay is a cost-effective and fast method for generating informative data for early preclinical/pharmacokinetic absorption, digestion, metabolism, and excretion studies of biotherapeutics ( Determination of metabolites was the most challenging aspect of this study

Theres not enough evidence to show the possible negative effects of taking high doses of vitamin B12.

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Vitamin B12 helps support: Healthy red blood cell production Normal nervous system function Energy metabolism Brain and cognitive function Reduction of tiredness and fatigue If your body does not get enough B12 or struggles to absorb it properly, symptoms can gradually develop