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ACE inhibitors or ARBs are first-line treatments that can slow progression by 30-50% when started early, even in patients without high blood pressure

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Similarly, decreased lactylation of malate dehydrogenase 2 at K241, coupled with reduced lactate production, leads to elevated levels of GSH and GPX4, thereby alleviating ferroptosis and improving mitochondrial function in myocardial IRI (120)

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Under the metabolic rheostat framework, SQOR expression and activity are highly context-dependent: upregulation protects tissues from ischemia/reperfusion injury and ferroptosis, whereas inhibition may be beneficial in chronic heart failure or early cancer by allowing endogenous H 2 S to accumulate