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There is a growing health and socioeconomic burden of obesity, with an increasing demand for effective anti-obesity drugs ideally comparable to bariatric surgery, the current gold-standard for obesity treatment which offers highly effective, long-lasting and life-extending results (4)

[4] In humans, Keutel syndrome is a rare recessive genetic disorder associated with abnormalities in the gene coding for MGP and characterized by abnormal diffuse cartilage calcification

In cultured cells, GLP-1 mediates its effects through G proteins linked to adenylyl cyclase, resulting in increased intracellular circulating adenosine monophosphate and activation of protein kinase A (PKA) [17]

Stopping without medical supervision may lead to deteriorating blood glucose control, potentially resulting in hyperglycaemia and increased risk of long-term diabetic complications

10.1186/s13059-014-0550-8 34 MiaoY.SunY.WangW.DuB.XiaoS

Khvatova, Natalia A