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The gedatolisib triplet, combining gedatolisib with palbociclib and fulvestrant, achieved a median progression-free survival of 9.3 months versus 2.0 months for fulvestrant alone, representing a 76% reduction in the risk of disease progression or death

Inhibition of vascular smooth muscle cell (VSMC) proliferation The proliferation and migration of normally quiescent VSMCs are central features of vascular diseases, including atherosclerosis and coronary restenosis (when treated arteries become blocked again) (47)

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