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In early 2023, OPM issued a letter to FEHB carriers related to the prevention and treatment of obesity

2015;10(4):e0123608

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Repeated use of the same site can cause minor tissue changes that slow uptake over time

C.StrassburgerK.NowotnyB.KolbH.NowotnyP.BurkartV.et al (2015)

In clinical practice, providers often observe that patients who progress steadily through lower stages without significant gastrointestinal symptoms tend to tolerate increases toward the higher tiers more comfortably than those who experienced ongoing discomfort earlier in treatment