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Studies have indicated that AOD-9604 can stimulate lipolysis without affecting insulin or IGF1 levels, suggesting that it may not lead to the development of diabetes or glucose intolerance

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The 50100mg range appears in protocols because it approximates allometric scaling from effective rodent doses, but rigorous human pharmacokinetic data validating those numbers is sparse

This clinical study demonstrates that NAD+ declines with age in humans, highlighting age-associated shifts in redox balance and NAD+ metabolism that may contribute to aging and disease