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We have previously shown the ability of verapamil to bind to purified human MRP1 11 , indicating it regulates MRP1 by interacting with it

With the newfound understanding that the TME is directly involved in events such as tumor progression and metastasis, and therefore plays a role in the efficacy of various treatments, it is important to consider not only the traits of cancer cells themselves but also the TME that they are found in, and whether it can be activated and used as a restorative agent (Hanahan and Weinberg, 2011

This underlines the importance of integrating microglia into the organoid model to mimic the complexity of the brain more accurately [31, 54]

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The method of embodiment 115, wherein the composition comprises from about 15 wt % to about 17 wt % poloxamer 407