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Beyond obesity and weight-loss maintenance, ROSE-010 has also shown clinically meaningful, statistically significant pain relief in a separate Phase 2a study of patients with irritable bowel syndrome (IBS), supporting its potential as the first targeted, on-demand therapy for acute IBS pain

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Symptomatic vitamin deficiency is more likely if the person is rendered achlorhydric (a complete absence of gastric acid secretion), which occurs more frequently with proton pump inhibitors than H 2 blockers

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If results remain unexplained, particularly with very high levels, further investigation may include imaging or haematology referral depending on clinical context and associated abnormalities

B12 is not a cure for clinical depression or anxiety, so persistent mood symptoms should be evaluated by a provider