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TNFR1 binds to several proteins, including tumor necrosis factor receptor type 1associated death domain (TRADD), TNFR1-associated receptor-interacting protein kinase, also called receptor-interacting protein kinase (RIPK), and TNF receptor-associated factor 2 (TRAF2) [208]

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It explicitly rejects a one-size-fits-all protocol in favor of individualized clinical discussion