This pharmacokinetic profile, combined with its amphiphilic character (allowing it to cross the blood-brain barrier), has sustained interest in DSIP as both a research tool and a subject of investigation in its own right
In laboratory and pre-clinical settings, DSIP has been studied as a uniquely multifunctional endogenous regulatory neuropeptide across sleep, stress, neuroendocrine, neuroprotection, and geroprotective research applications: Sleep biology delta-wave SWS promotion, sleep homeostasis modulation, sleep efficiency and sleep latency research Sleep EEG research delta-wave induction, SWS vs REM sleep architecture, and sleep stage analysis via polysomnography Sleep neuromodulator pharmacology DSIP vs sedatives and hypnotics
doi:10.1016/j.rcl.2006.07.005
Heme a is also a modified iron protoporphyrin IX
Delta Sleep Inducing Peptide (DSIP): Reviewing the Research. BioLongevity Labs , 21 Oct
Calderon-Montano JMBurgos-MornEPrez-GuerreroCLpez-LzaroM