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MacQueen and Frodl, 2011)

Conflicts of interest Won-Young Lee and Eun-Jung Rhee are co-editors-in-chief of this journal, but were not involved in the peer reviewer selection, evaluation, or decision process of this article

GLP-1 binds to its specific receptor (GLP1R), promoting insulin release

and in humans, HPX recycling has been implicated from plasma heme clearance studies ( In cultured cells, hemeHPX binding and heme delivery initiate a cytoprotective program of events (Montecinos et al., 2019), including the induction of the heme degrading enzyme heme oxygenase (HMOX1)

Interestingly, at least Yasuda and colleagues also saw a significant reduced food intake in the KO rats irrespective of the diet (45), which might be due to changed receptor specificity of neuropeptide Y (NPY), which was shown to be more potent in KO rats to influence food intake and feeding motivation (49)

McClure et al