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Thigh injection may be the optimal starting site for retatrutide initiation , with gradual introduction of abdominal injection as tolerance develops

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Meanwhile, caffeine is usually absorbed quickly in the stomach and small intestine

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A light breakfast 30 to 60 minutes before or after injection can buffer this effect, but that requires planning your morning around the shot rather than the other way around

Consistency at a "good enough" time beats constantly chasing the theoretically "perfect" time