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M-CuP has antioxidant activity by increasing antioxidant enzymes and superoxide dismutase (SOD) activity, mainly neutralizing ROS by scavenging harmful oxygen-derived free radicals 66

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J Immunol 192(3):12671276

For example, a meta-analysis of 31 randomized, controlled trials reports that the most common side effects observed in the hGH studies and their respective incidences were [16]: Soft tissue edema: 50% Insulin resistance: 22% Arthralgias: 21% Carpal tunnel syndrome: 19% These side effects are transient and usually subside as the patient gets used to the therapy

Severe niacin deficiency, known as pellagra, has been historically associated with poverty and consumption of a diet predominantly based on corn, which is low in bioavailable niacin (25, 26)

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