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Such activation results in the expression of pro-inflammatory cytokines, including TNF- , IL-1 , and IL-6 , which are instrumental in promoting inflammation and are vital for the control of viral replication ( IL-7 , IFN- , and chicken myelomonocytic growth factor (cMGF), alongside a marked downregulation of IL-12 and IL-13 expression ( IL-7 expression

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This provides the rationale for the perioperative use of immunonutrition formulas containing specific nutrients (e.g., arginine, -3 PUFAs, nucleotides), aiming to reduce postoperative complication risks by modulating the immune response (57, 58)