Search strategy and screening According to Participants, Interventions, Control, and Outcomes (PICO) principles [23], the following focused question was set: Which targeting ligands have been employed to deliver protein-coding nucleic acids (pDNA and mRNA) with lipid non-viral vectors to tissues/organs relevant in the treatment of FD? The research question was conceived as follows: (P) participant: animals/humans intravenously administered
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The medication is absorbed by the blood vessels in the subcutaneous tissue and distributed throughout the body
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