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A key challenge stems from the structural complexity of conjugating a large antibody (~150 kDa) with a multifunctional PROTAC, often generating heterogeneous species that are difficult to optimize

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(NIDDK) Blood sugar becomes more stable, which can reduce the drive to eat in response to large metabolic swings

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Epifluorescence and confocal analyses of the protein subcellular localization indicated that in animals treated with DMF, Nrf2 translocates into the nucleus of a large proportion of choroidal epithelial cells within 90 min of treatment (Fig