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Week 10: 265.5025.81)

Increasing complexity of Nlrp3 inflammasome regulation

Shahien M, Elgendy B, Hegazy L, Patouret R, Walker JK, Burris TP

This required a lot of extra coordination and meetings across the three Gensler teams

We refer readers to the above noted section for a full discussion of the comments and our responses regarding CPT code 64568

Short-Acting vs Long-Acting Formulations Short-acting GLP-1 medications have shorter half-lives and more frequent dosing: Exenatide immediate-release (Byetta) Half-life of approximately 24 hours, administered twice daily Lixisenatide (Lyxumia) Half-life of approximately 3 hours, administered once daily Long-acting formulations demonstrate markedly different pharmacokinetics: Semaglutide Half-life of approximately 7 days (168 hours), administered weekly Dulaglutide Half-life of approximately 5 days (120 hours), administered weekly Liraglutide Half-life of approximately 13 hours, administered daily Exenatide extended-release Half-life of approximately 2 weeks, administered weekly Clearance Pathways GLP-1 medications are eliminated from the body through different pathways depending on the specific agent: Exenatide and lixisenatide are primarily eliminated through the kidneys