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Ergothioneine meets several criteria for longevity vitamin classification: Diet-derived (cannot be synthesized by humans) Has a dedicated evolutionary conserved transporter Accumulates in stress-vulnerable tissues Is inversely associated with markers of aging and disease risk Dr

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They also secrete LOXs, which catalyze PUFA oxidation and lipid peroxidation

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IBCC Hypoglycemia (Farkas J, 2025)