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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

Specifically, FMN and FAD act as cofactors for certain enzymes (flavoproteins) involved in electron transfer reactions (e.g., energy production reactions, metabolic conversion of essential micronutrients such as that of folate, vitamin B 6 , niacin), drug metabolism, toxin detoxifying, and electron scavenging pathways

Katsi V et al

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