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Patients with unstable cardiovascular disease, poorly controlled hypertension, or significant hypotension may require additional monitoring or alternative therapies

Cocarboxylase is an integral non-protein part of enzymes and takes an active part in metabolic processes, for example, in carbohydrate metabolism

Studies are limited but show that glycine may also be good for sleep because it lowers core body temperature and helps with REM sleep

& Khan, R

However, oral supplementation of L-arginine, the precursor for NO synthesis, has been shown to be largely ineffective at increasing NO synthesis and/or bioavailability for several reasons, which makes L-citrulline much more ideal for boosting levels of L-arginine and subsequently NO