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Every participant in the clinical trials who maintained excellent body composition (losing primarily fat rather than muscle) hit this target consistently

In a 2018 analysis of clinical trial data, several researchers working with Novo Nordisk, the drugmaker for Ozempic and Wegovy, found that the drugs were safe and effective in adults over age 65, but noted that older adults reported discontinuation due to gastrointestinal issues at a higher rate than younger participants did

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J Clin Endocrinol Metab (2008) 93(7):26708

Treatment with a GLP-1 receptor agonist diminishes the decrease in free plasma leptin during maintenance of weight loss

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