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doi: 10.1038/s41598-019-42286-8 238 ZhaoJ.DaiT.DingL.LiangY.YuanW.JiangY.et al

For DPP-4 inhibitors, the overall number of AE reports and biliary disorder AE reports demonstrated an upward and then a downward trend, reaching a peak in 2015 with 132 biliary disorder AE reports

The weight difference between the groups also appears to be widening from one to six months post-intervention, scientists say

How effective and safe are prescription weight-loss drugs

Most users notice visible improvement in dark spots and skin tone within two to four weeks of consistent use

However, this also means side effects and appetite suppression don't stop immediately when you pause or discontinue treatment