5 Potential therapeutic targets Up to now, clinical studies targeting SCFAs to improve NAFLD are scarce, and the direction of drug development is mostly based on the promotion of SCFA-producing advantageous microbiota, such as increasing the abundance of Bacteroidetes, Ackermannia, Bifidobacterium, Lactobacillus , and Prevotella , and decreasing the ratios of Firmicutes and F/B (Castillo et al., 2021)
Statistical Analysis Each experiment was repeated three or more times with three experimental replicates, and the results were expressed as the mean SD
Handattu et al., 2013), tau hyperphosphorylation (Ghosal et al., 2013), and glial activation in mouse models of amyloid pathology
Uses: Treat B12 deficiency (pernicious anemia, malabsorption, certain diets/drugs)
Biol Psychiatry (2017) 82:47287
Detection windows vary by specific compound