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We first tested this combination in two studies using a DIO mouse model to assess changes in adipose, skeletal muscle mass, and liver fat

Anagnostou E, Soorya L, Chaplin W, Bartz J, Halpern D, Wasserman S et al (2012)

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Cardiovascular aging: Both estrogen and GLP-1 protect the endothelium

And yesthank you for noticing

The "best" dose is the one that is both effective and tolerable for you long-term