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Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury

2024;396:111029 Janssen W, Pullamsetti SS, Cooke J, Weissmann N, Guenther A, Schermuly RT

The two compounds share the core sequence corresponding to residues 176-191 of human growth hormone

One was clinical

Luo W, Ai L, Wang BF, Zhou Y

27, 33, 34, 35, 36, 37, 38, 39 As mentioned above, the thermolabile T variant of the MTHFR C677T polymorphism is associated with increased vulnerability to oxidative stress and a decreased DNA methylation capacity