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Alterations in microbial communities and their metabolites have been linked to key pathological features of PCOS (116, 117), including insulin resistance, hyperandrogenism, and chronic low-grade inflammation, supporting the concept of a gutmetabolismreproductive axis in which intestinal microbial ecosystems influence both metabolic and endocrine homeostasis (73)

(n = 9) and 300 mg t.i.d

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[1] In a 12 week randomised clinical trial, subjects receiving AOD9604 lost, on average, 1.8 kg more than those receiving placebo