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After completion of the reaction, the solvent was removed under reduced pressure, and the residue was dissolved in ethyl acetate

Changes in the expression of those signaling molecules could be part of the underlying mechanism modulating osteoclastogenesis in response to IGF-I (Figure 2)

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Beyond physical attachment, adhesion activates host signaling pathways upregulates tight-junction proteins and induce antimicrobial peptide secretion, strengthening the barrier and limiting pathogen invasion (Wang et al., 2025)