Published Phase 3 efficacy-estimand data shows retatrutide at 12 mg producing about 28.7% weight loss over 68 weeks (TRIUMPH-4) versus orforglipron at 36 mg producing about 12.4% over 72 weeks (ATTAIN-1)
Keep the needle in the vial for the next step
If you reach the end of week eight and are still experiencing daily nausea at the 4mg dose, staying at 4mg for an additional two to four weeks until your GI system stabilizes is a rational, evidence-supported choice
Mild redness or tenderness at the injection site, slight headache, or brief lightheadedness all typically minimal and short-lived
Try it, share it with someone who hates missing out on dessert, and let me know how it changes your snack game
Compounded retatrutide typically runs $200 to $500 per month, depending on dose and provider